Endocrine Abstracts

Aim: Acromegaly is an endocrine disorder characterized by sustained elevation of circulating GH and insulin-like growth factor (IGF1). IGF1 is a potent mitogen and has a role in the transformation of normal cells to malignant cells. Micronucleus (MN) frequency is a biomarker of chromosomal damage, genome instability and cancer risk. Our study aimed to evaluate spontaneous MN frequency by using the cytokinesis block MN assay to determine genetic damage in lymphoytes of patients...

Objectives: It has been recently recognized that GH may have a role in hematopoiesis and immune system. However, there are conflicting data regarding the effects of GH deficiency (GHD) and/or GH replacement therapy in GH deficient patients on hematopoiesis and immune system. The aim of the present study was to investigate the peripheral blood cell counts, T- and B-lymphocyte subsets and immunoglobulin levels before and after GH replacement therapy in patients with adult onset ...

Objectives: Evaluation of the HPA axis is still a big challenge. This study was performed to compare 1 μg ACTH, 250 μg ACTH and glucagon tests for evaluation of HPA axis in healthy male and female subjects with different ages.Materials and methods: This study was carried out on 57 healthy individuals (29 men, 28 women) between 20 and 70 years of age (the number and gender of the subjects are approximately equal for each decade). Low dose short ...

Introduction: Presence of GH receptor in human skin and its appendages suggests a direct effect of GH on skin characteristics. Wet and oily skin due to hyperhidrosis and increased sebum production were described in acromegaly patients.Objective: The aim of the study was to examine the hydration via capacitance, sebum content, transepidermal water loss, pH and temperature of the skin in patients with acromegaly. The data were compared with that of control...

Objective: Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 1 (VEGFR1) are known to be related to thyroid tumorigenesis, but data are limited about their relationship with insulin like growth factor 1 (IGF1) and IGF1 receptor. The aim of this study was to clarify the role of VEGF, VEGFR-1, IGF1 and IGF1 receptor in thyroid tumorigenesis.Methods: We examined 40 patients with differentiated thyroid carcinoma (DTC) a...

Hirsutism, which is characterized by excessive growth of terminal hair in a male pattern, is a common clinical condition in women. Among its etiologies, idiopathic hirsutism (IH) is considered to be one of the most common forms of hirsutism. We have previously shown the presence of insulin resistance in women with IH and our aim was to investigate the effects of metformin therapy in women with IH. The study was approved by the local Ethics Committee. Sixteen women with IH (mea...

Some of the patients with hyperandrogenemia are characterized by regular cycles and normal ovaries on USG and named as idiopathic hyperandrogenemia (IHA). To clarify the pathophysiology of IHA we have investigated both the adrenal and ovarian functions, and insulin resistance in 20 patients with IHA and 10 healthy women. The study was approved by the local Ethics Committee. The patients have at least one increased serum androgen. ACTH stimulation test, buserelin test and an OG...

AimGlucagon stimulation test (GST) is used to assess hypothalamo-pituitary-adrenal (HPA) and GH axis with an incompletely defined mechanism. Glucagon has physiological effects on body weight and metabolic parameters and some of these effects are suggested to occur via fibroblast growth factor-21 (FGF-21) which is a circulating hepatokine. FGF-21 was also shown to affect HPA and GH axis in rodents. The aim of the present study was assess if glucagon acted...

Backgound: Familial hypertriglyceridemia may lead to acute pancreatitis also during pregnancy in some cases. We present two cases with hypertriglyceridemia-induced pancreatitis that recurred despite diet and medical therapy during pregnancy.Case presentation: Twenty-eight-year-old woman presented with hypertriglyceridemia-induced pancreatitis (serum triglyceride: 8502 mg/dL) that was complicated with respiratory distress at 25 weeks of gestation. Followi...

Objectives: Acute bacterial or viral CNS infections have been shown to result in hypopituitarism during the acute phase, and 6–24 months after the event in a few studies. However, there are no data in the literature regarding the long term pituitary functions after acute CNS infections. This cross-sectional study was designed to evaluate the pituitary functions long-term after the acute bacterial or viral CNS infections.Methods: 19 patients with age...